Richard Zelman MD | Mechanisms of Cardiac Cell Therapy

Regeneration of Cardiomyocytes: The transplanted cells can differentiate into cardiomyocytes, replacing the cells lost during a heart attack and restoring the heart's pumping ability.

Paracrine Signaling: Even if the transplanted cells do not directly replace damaged tissue, they can release growth factors and cytokines that stimulate endogenous repair mechanisms, promote angiogenesis (formation of new blood vessels), and reduce inflammation and fibrosis.

Improved Electrical Conduction: By integrating into the existing cardiac tissue, the new cells can help restore normal electrical conduction pathways, reducing the risk of arrhythmias that often accompany heart failure.